FORMULATION AND EVALUATION OF FAST DISSOLVING BUCCAL FILM OF ENALAPRIL MALEATE

Formulation and Evaluation of Mucoadhesive Buccal Films of Enalapril Maleate

Enalapril maleate is used in the treatment of hypertension and angina pectoris. It shows low bioavailability due to high hepatic first pass metabolism. Hence the present work was undertaken to formulate mucoadhesive buccal films of enalapril maleate with an objective to improve therapeutic efficacy, patient compliance and the bioavailability. In the present study ten formulations of mucoadhesiv...

Formulation & Evaluation of Fast dissolving Buccal films of Sertraline

The hydrochloride of Sertraline is a white crystalline powder; slightly soluble in water and freely soluble in ethanol [1]. It is a drug of selective serotonin reuptake inhibitors (SSRI) that is chemically unrelated to other SSRIs, tricyclic, tetracyclic, or other available antidepressant drugs. Sertraline inhibit the inactivation of serotonin (5hydroxytryptamine or 5-HT) by blocking its absorp...

Formulation Development and Evaluation of Fast Dissolving Film of Telmisartan

Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it sh...

Enalapril Maleate Loaded Pullulan Film for Mucoadhesive Buccal Drug Delivery Applications

Pullulan, a water soluble, bioadhesive and biocompatible biopolymer is used as an efficient matrix for enalapril maleate film preparation. The obtained film contains as much as 67% of enalapril maleate, relative to the initial amount used for experiments. The drug content was evaluated by using 1 H-NMR and UV-vis spectroscopy. The pullulanenalaprilmaleate blends exhibit good physicochemical pro...

formulation and evaluation of triamcinolon acetonid bilayer buccal adhesive film